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Similarly, Cys depletion can trigger ferroptosis, mainly due to impaired GSH biosynthesis and defective Fe/S cluster biogenesis, which result in an iron starvation response, increased iron uptake, and subsequent ferroptotic cell death [79,80]

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They must be handled by qualified researchers in compliance with applicable Irish and EU regulations and institutional ethics guidelines

Self-renewal refers to the ability of stem cells to divide symmetrically or asymmetrically to produce daughter cells that retain their stem cell identity [92]

Notably, Cdc42 was found to be significantly elevated in IFFO1 / cells (Fig